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On the other hand, NO co-transmission may also be beneficial in some pathological contexts, especially early in the disease course of AD, in part by promoting protective neuroplasticity via its canonical role in LTP ( Polyamines: agmatine, spermidine/spermine, and putrescine-derived GABA Synthesis, vesicular loading, and transduction of agmatine co-transmitter Agmatine (Agm) is a polyamine primarily produced from the decarboxylation of L-arginine, putting its synthesis in competition with NO and urea production (Figure 1)